Yobsalax N.G
A unique herbal formula designed to help regulate bowel function and thus aid in the effects of constipation
A combination of a herbal mixture that helps relieve symptoms that are characteristic of the constipation phenomenon such as: recurrent abdominal pain, difficulty emptying, bloating, gas and more. The combination of plants affects the peristaltic action (intestinal motility) in a gentle way, causing an increase in water content and moisture in the intestinal walls, which is most necessary for normal bowel movements.
Each package contains: 60 vegicaps.
Recommended use: Two capsules, once a day.
Yobsalax N.G Benefits
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A novel preparation that improves a range of constipation indicators (bowel movement frequency, consistency of stools, and laxative dependence) .
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Yobsalax N.G promotes digestive health by facilitating the breakdown of fats and sugars in the digestive system.
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Encourages the cleansing of the gastrointestinal tract, forcing the body to eliminate harmful chemicals and toxins that would normally hinder the digestion process.
Description
Constipation is defined as having infrequent bowel movements, often fewer than three per week, and difficulty passing stools. Most people experience occasional constipation, but about 14% of adults suffer from chronic constipation. Many people turn to laxative medications, but these can lead to dependence and troubling side effects. Natural interventions can be used to help relieve constipation including effervescent magnesium and vitamin C, fiber, and probiotics.
Causes and Risk Factors
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Impaired peristalsis (wave-like contractions of the gut)
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Blockages, neurological and hormonal conditions, and medications such as opioids
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Female gender (two to three times the risk of males) and advanced age (with greatest prevalence in those older than 70)
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Most people experience occasional constipation, but about 14% of adults suffer from chronic constipation (Basilisco 2013; Rao 2014; Quigley 2011; Jamshed 2011)
These people often turn to laxative medications, but these drugs are sometimes ineffective and can cause troubling side effects such as bloating, diarrhea, and loss of bowel control. Moreover, laxative overuse may lead to dependence (Wang 2013; Leung, Rao 2011; Basilisco 2013; Pare 2014; Mayo Clinic 2014a). -
For some, constipation can often be relieved without harsh laxatives by increasing fiber and fluid intake as well as physical activity (Rao 2014; Rush 2002; Attaluri 2011).
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Others require more aggressive approaches using natural interventions to evacuate the bowels. These include effervescent magnesium and vitamin C powder, supplemental fiber such as psyllium, and probiotics. Other strategies can be helpful as well: avoiding foods that can slow gut motility (eg, eggs, meat, and dairy) (UU 2015b) and eating more foods with laxative properties (eg, prunes and kiwifruit) (Rush 2002; Attaluri 2011; Rao 2014).
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Many older people dismiss declining bowel function as a normal part of the aging process and learn to live with unsatisfactory evacuation. But constipation should not be ignored. Severe chronic constipation can lead to problematic complications like fecal impaction and fissures (Basilisco 2013; Jamshed 2011; Rogers 2013; Mayo Clinic 2012).
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The large intestine, or colon, is the final major segment of the digestive tract (CCS 2015). Waves of muscular contractions called peristalsis propel fecal material through the colon (Leung, Riutta 2011). These muscular activities are coordinated by signals from the nervous system and neurohormones like histamine and serotonin (Lee 2014; Wood 2007). Colonic peristalsis is naturally strongest upon waking in the morning and after meals, and insufficient peristalsis leads to constipation (Yu 2014; Hendricks 1997).
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The Gut-Brain Axis
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The network of nerves that controls gut activity, known as the enteric nervous system, contains as many nerve cells as the spinal cord (Wood 2007; Daulatzai 2014). The enteric nervous system and central nervous system are functionally interdependent. In other words, dysfunction originating in the central nervous system can give rise to problems in the enteric nervous system, and dysfunction originating in the enteric system may compromise central nervous function (De Palma 2014).
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This reciprocal relationship between the gastrointestinal tract and the nervous system has been called the “gut-brain axis” (Daulatzai 2014; O'Malley 2011; Lee 2014; De Palma 2014). Functional (primary) constipation is thought to involve gut-brain axis dysfunction (De Palma 2014). Bi-directional dysfunction of this axis also contributes to irritable bowel syndrome (Daulatzai 2014; O'Malley 2011; De Palma 2014).
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Researchers have found especially strong correlations between chronic constipation and two chronic neurological diseases: Parkinson’s disease and Lewy-body dementia (in which abnormal protein deposits called Lewy bodies build up in brain cells) (Idiaquez 2011; Postuma 2013; Weerkamp 2013). In one study, older individuals with a history of chronic constipation were more than three times as likely to develop Parkinson’s disease during an average 5.5 years of follow-up, and those with the most severe constipation had the greatest risk (Lin 2014). Other neurological diseases that have been correlated with constipation include restless leg syndrome (Shneyder 2013) and Alzheimer’s disease (Zakrzewska-Pniewska 2012).
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Inflammation is thought to underlie the connection between constipation and neurological disease. Disruptions in the gut microenvironment contribute to gastrointestinal symptoms as well as neurological problems; degradation of the gut barrier promotes systemic inflammation, which in turn promotes neuroinflammation and subsequent cognitive dysfunction .(information source)
Yobsalax N.G Ingredients
Aloe Ferox
Aloe vera latex is commonly used in the treatment of constipation (de Witte 1993); the laxative effect of the anthraquinone glycosides found in Aloe vera latex is well established (Ulbricht et al. 2008). In a double-blind, randomized, controlled trial of 28 healthy adults, aloin was reported to have a laxative effect compared to a placebo that was stronger than the stimulant laxative phenolphthalein (Chapman and Pittelli 1974). In subjects with chronic constipation, a novel preparation containing Aloe vera, celandine, and psyllium was found to improve a range of constipation indicators (bowel movement frequency, consistency of stools, and laxative dependence) in a 28-day double-blind trial; however, the effect of Aloe vera alone was not investigated in this study (Odes and Madar 1991). Aloe vera laxative preparations have been approved by the German Commission E governmental regulatory agency for use in the treatment of constipation as a second-line agent; however, Aloe latex is no longer recognized as an over-thecounter drug by the U.S. Food and Drug Administration due to a lack of sufficient data to establish its safety for use as a laxative.
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Myrrh
A peptic ulcer is defined as a lesion in the epithelium covering all of the digestive tract. It interrupts the integrity of the gastrointestinal mucosal layer in the esophagus, stomach, and upper part of the small intestine. A gastric ulcer is the most prevalent gastrointestinal disorder associated with an inflamed disruption in the mucous membrane layer of the stomach. The annual frequency of this disease is globally about 8% . Alcohol consumption has been linked to gastric mucosal inflammation, ulcers, and gastric cancer. The gastric ulcer has been developed by multiple endogenous aggressive factors such as high pepsin activity, bile reflux, abnormal gastric motility, minimum blood supply, hydrochloric acid (HCl) secretion, and Helicobacter pylori infection. Furthermore, inappropriate eating habits, chemical agents as alcohol , stress , smoking , and prolonged excessive use of irritant drugs as non-steroidal anti-inflammatory drugs are exogenous factors of gastric ulceration. Ethanol is one of the primary causes of gastric ulcers and is used as a model for evaluating the gastroprotective effects of various drugs. Ethanol is metabolized into acetaldehyde by the action of alcohol dehydrogenases; then, it is further metabolized to acetic acid, which has toxic effects on the stomach. In addition, acetaldehyde was generated by a microsomal ethanol oxidizing system (cytochrome P450 2E1) and catalase. Lessening gastric attacker mediators and promoting conservative gastric factors are the main therapeutic tools for restoring gastric slough.
The mechanism of gastric slough cure includes the reconditioning of the gastro-defensive ‘factors’ balance, creation of gastric mucosal cells, antioxidant status, and anti-inflammation effect. Commiphora myrrh belongs to the family of Burseraceae and is grown in East Africa, Saudi Arabia, and India . Many scientific studies have demonstrated the numerous benefits of using myrrh in medicine. These studies revealed that Commiphora species contained anti-inflammatory compounds, antinociceptive, immunostimulant , analgesic , and antioxidant effects. Few studies have been reported to investigate the potential effect of myrrh on the protection and treatment of gastric ulcers. Moreover, the exact mechanisms by which myrrh directly or indirectly affect gastric ulcers have not been elucidated. In addition, there is no clear report on the healing effect of myrrh on the gastric ulcer. It is required to conduct more detailed investigations to establish the antiinflammatory, antioxidant properties, anti-apoptotic, and proliferating effect of myrrh in gastric ulcer treatment. (information source)
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Damiana leaf extract
This versatile herb will promote digestive health by facilitating the breakdown of fats and sugars in the digestive system. This mechanism is beneficial as it increases the body’s nutrient absorption rate, thus ensuring the body receives the most nutrients found in the food we eat. Damiana also encourages the cleansing of the gastrointestinal tract, forcing the body to eliminate harmful chemicals and toxins that would normally hinder the digestion process. This natural herb can also be used to treat dyspepsia or impaired digestion as it actively slows down the digestive process. (information source)
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Ziziphus jujuba
Jujube (Ziziphus jujuba), as an edible-medicinal fruit, is an important Chinese herbal medicine, which has the potential to become a more safe and healthy feed additive than general herbal medicine. It contains many biologically active components, such as vitamin C, phenolics, flavonoids, triterpenic acids, polysaccharides, saponinsand so on (Gao et al., 2013；Bai et al., 2016). The previous pharmacological studies revealed that these bioactive compounds of jujube had several beneficial effects on host such as anticancer, anti-inflammatory, immunostimulating, antioxidant, hepatoprotective as well as gastrointestinal protective activities. As an important part of the digestive system, the intestine is not only closely related to the digestion and absorption of nutrients, but also closely related to the body's immunity and health (MontalbanArques et al., 2015, Haygood and Jha, 2018, Dawood, 2020). The diet components can affect intestinal health through several pathways, including intestinal morphology, microbial diversity, intestinal barriers, oxidative status and digestive enzyme activity. (information source)