Mannitol
A natural supplement for degenerative disease of the central nervous system
Has been shown to be a contributing factor in the symptoms of Parkinson's disease, along with being an alternative natural sweetener to sugar. Mannitol is a natural sweetener that is a sugar substitute in food products, for people suffering from diabetes or for people with an awareness of a healthy lifestyle and reduced use of processed sugar.
Each package contains: 300 gr mannitol.
Recommended use: 5 gr, twice a day.
Mannitol Benefits
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Mannitol interferes with the formation of α-synuclein fibrils, inhibits the formation of α-synuclein oligomers and leads to phenotypic recovery of impaired motor functions.
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Safety of long-term use of oral mannitol, tolerable dose and possible benefit.
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Effective for the prevention of AD through inhibition of Aβ and tau aggregation.
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Anti-parkinsonism properties, possibly due to the existence of L-dopa, which is a precursor of the neurotransmitter dopamine.
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The natural L-dopa is less toxic. It has a shorter onset of action, but it has a longer therapeutic effect, which could delay the need for combination therapy.
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Long-term use of synthetic L-dopa can cause serious side effects such as dyskinesia and abnormal involuntary movement. A search for more effective treatment with lower side effects is significant for improving the quality of life of Parkinson’s patients taking this drug.
Description
Has been shown to be a contributing factor in the symptoms of Parkinson's disease, along with being an alternative natural sweetener to sugar. Mannitol is a natural sweetener that is a sugar substitute in food products, for people suffering from diabetes or for people with an awareness of a healthy lifestyle and reduced use of processed sugar.
In Parkinson's, nerve damage occurs in the brain. These processes are known to result from the crystallization of the alpha-synuclein protein. Studies have shown that mannitol has a 70% effect on reducing the formation of these lumps.
The velvety bean - Mucuna, helps as a rich and available source of dopamine to provide the body with the existing dopamine deficiency, in parallel with the action of Mannitol. Mannitol Has been shown to be a contributing factor in the symptoms of Parkinson's disease, along with being an alternative natural sweetener to sugar.
Mannitol is a natural sweetener that is a sugar substitute in food products, for people suffering from diabetes or for people with an awareness of a healthy lifestyle and reduced use of processed sugar. In Parkinson's, nerve damage occurs in the brain. These processes are known to result from the crystallization of the alpha-synuclein protein. Studies have shown that mannitol has a 70% effect on reducing the formation of these lumps. The velvety bean - Mucuna, helps as a rich and available source of dopamine to provide the body with the existing dopamine deficiency, in parallel with the action of Mannitol.
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Parkinson’s disease is a neurological disorder that causes movement problems and can progress into dementia. It’s caused by the loss of cells in the brain that produce dopamine, a neurotransmitter that controls movement and coordination. Several factors can contribute to the loss of dopamine-producing cells.
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Dr. James Parkinson first described the motor system disorder known today as Parkinson's disease in an 1817 paper entitled "An Essay on the Shaking Palsy."3 In his report, Dr. Parkinson described several characteristic traits, including an abnormal posture and gait, and partial paralysis with muscle weakness; he also described the progression of the disease. The contribution of more clearly defining the condition, theretofore known as paralysis agitans, led to the adoption of Dr. Parkinson's last name as the moniker that remains with us today.
What is Parkinson's Disease?
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Parkinson’s disease is a degenerative disease of the central nervous system resulting from depletion of dopamine-producing cells in the brain. While the underlying cause of the disease is not clearly understood, depletion of dopamine-producing cells may be exacerbated by oxidative stress, inflammation, and mitochondrial dysfunction. Parkinson’s patients generally experience decline in motor function and eventually cognitive decline and dementia.
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Parkinson’s may manifest as a primary condition or secondary to another condition, such as a brain tumor, exposure to toxins (like helicobacter pylori), or after a viral infection.
What are the Risk Factors for Parkinson’s Disease?
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Family history/genetic predisposition
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Exposure to pesticides or other toxins like carbon monoxide
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Brain tumor ● Viral encephalitis
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AIDS
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Chronic constipation
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Repeated blows to the head (eg, professional fighters or football players)
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Certain medications
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Stroke
What are the Signs and Symptoms of Parkinson’s Disease?
Note: Symptoms of Parkinson’s generally progress slowly. Tremors are often the first sign.
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Tremors, often in the hand
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Muscle cramping or rigidity
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Pain throughout the body
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Slow movements
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Incontinence or constipation
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Difficulty swallowing and/or controlling saliva
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Dizziness
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Sleepiness
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Depression and/or anxiety
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Hallucinations or frightening dreams
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Cognitive decline and/or dementia
Mannitol Ingredients
Mannitol
a natural alcoholic-sugar, was recently suggested as a potential disease-modifying agent in Parkinson's disease. In animal models of the disease, mannitol interferes with the formation of α-synuclein fibrils, inhibits the formation of α-synuclein oligomers and leads to phenotypic recovery of impaired motor functions. Parkinson's patients who consume mannitol report improvements of both motor and non-motor symptoms. Safety of long-term use of oral mannitol, tolerable dose and possible benefit, however, were never clinically studied. We studied the safety of oral mannitol in Parkinson's disease and assessed the maximal tolerable oral dose by conducting a phase IIa, randomized, double-blind, placebo-controlled, single-center, doseescalating study (ClinicalTrials.gov Identifier: NCT03823638). The study lasted 36 weeks and included four dose escalations of oral mannitol or dextrose to a maximal dose of 18 g per day. The primary outcome was the safety of oral mannitol, as assessed by the number of adverse events and abnormal laboratory results. Clinical and biochemical efficacy measures were collected but were not statistically-powered. Fourteen patients receiving mannitol completed the trial (in addition to eight patients on placebo). Mannitol-related severe adverse events were not observed. Gastrointestinal symptoms limited dose escalation in 6/14 participants on mannitol. None of the clinical or biochemical efficacy secondary outcome measures significantly differed between groups. We concluded that long-term use of 18 g per day of oral mannitol is safe in Parkinson's disease patients but only two third of patients tolerate this maximal dose. These findings should be considered in the design of future efficacy (information source)
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Mucuna
What is Mucuna Pruriens?
MP, also referred to as the velvet bean, is a legume that grows in tropical and subtropical areas across the world including Africa, Asia, the Caribbean and the Pacific Islands. Although the beans can be used as a source of food after they are boiled, MP is also a medicinal plant, used for millennia in traditional Ayurvedic Indian medicine, for a variety of conditions. MP has been investigated for its anti-diabetic, anti-microbial, anti-oxidant, antiepileptic, and anti-depressant properties, to name a few.
Because it contains 6-9% levodopa by weight however, one of its main medicinal uses is to counteract parkinsonian symptoms. It is important however to understand more about this potential remedy – including its shortcomings – before jumping on the MP bandwagon. (information source)