HR Growth
Men Aren't The Only Ones Who Go Bald.
It's A Reality For Women, Too
Half of men experience some degree of hair loss by the time they turn 50. Forty percent of women are affected by age 70. “Pattern” hair loss is the most common cause of hair loss in both genders. In genetically susceptible individuals, the male hormone dihydrotestosterone, or DHT, contributes to pattern hair loss (Qi 2014; Santos 2015; Mayo Clinic 2015).
An autoimmune condition called alopecia areata is another relatively common cause of hair loss, affecting about 2% of people at some point during their lives (Stough 2005; Levy 2013; Qi 2014; Hawit 2008). Other less common causes of hair loss include some medications, severe trauma or stress, and nutritional deficiencies.
Each package contains: 30 vegicaps.
Recommended use: One capsule, once a day.
HR Growth Benefits
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1 capsule per day.
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Clinical study supported.
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The modality treats women and children as well as men.
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HR GROWTH responses to the modality is 3 times quicker by average than others.
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All the ingredients are licensed as food supplements.
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No side effects.
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Efficacy of 67% for hair regeneration.
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Designed for all types of Alopecia including Alopecia Areata.
Description
Two medications are available to treat pattern hair loss:
minoxidil (Rogaine) for men and women as an over-the-counter topical treatment, and finasteride (Propecia), an oral prescription drug for men that blocks the conversion of testosterone to DHT. Unfortunately, neither of these medications is remarkably effective, and both have side effects (Mayo Clinic 2015; Levy 2013). Surgical hair restoration is an effective but expensive and invasive option for both men and women with long-term hair loss (Levy 2013; Stough 2005).
For people undergoing chemotherapy—one of the most common medical causes of hair loss—scalp cooling can help maintain hair density (Shin 2015). Intriguing new scientific findings are uncovering the next generation of therapies to combat hair loss. For instance, several trials have found that injecting platelet-rich plasma into the scalp can safely increase hair density (Ferneini 2016; Singh 2016). And the recent discovery that stem cells in hair follicles regulate hair growth has led to new avenues of research that may yield more promising treatments (Santos 2015). In addition to a healthy diet (Lin 2016), a number of integrative interventions, including solubilized keratin (Beer 2014), essential fatty acids (Le Floc'h 2015), zinc (Karashima 2012), and saw palmetto extract (Murugusundram 2009; Rossi 2012) may prevent hair loss and promote healthy hair growth.
An average person’s scalp contains 250,000‒500,000 hair follicles. Each follicle undergoes repeated cycles of three phases (Santos 2015): anagen, the growth phase, during which hair elongates; catagen, the regression phase, during which the follicle shrinks and detaches from its hair; and telogen, the resting phase. On a healthy scalp, about 90–95% of hair follicles are in the anagen phase at any given time (Qi 2014; Santos 2015). Under normal circumstances, scalp hair shedding of 50‒ 150 hairs per day is matched by new hair growth at the same rate, so there is no net loss or gain (Fiuraskova 2003; Ahanogbe 2015). Cells at the base of the hair follicle, in a region called the dermal papilla, are responsible for initiating and regulating the hair follicle cycle (Driskell 2011). These dermal papilla cells are regulated by hormones, growth factors, and inflammatory cytokines (Santos 2015; Inui 2013).
Medical Conditions Associated with Hair Loss
Cardiovascular disease and metabolic syndrome. Androgenetic alopecia may be an indicator of cardiovascular risk. In one study, 80 men and 70 women with early-onset androgenetic alopecia had significantly higher triglyceride as well as total and LDL-cholesterol levels, and lower HDL cholesterol, than men and women without hair loss (Arias-Santiago 2010). In another study, male androgenetic alopecia was correlated with high blood pressure (Ahouansou 2007).
Early onset of pattern hair loss may be a stronger predictor of cardiovascular disease than later-onset androgenetic alopecia. In one study, men with early-onset androgenetic alopecia were more than three times as likely to need coronary artery bypass surgery before age 60 than men with later-onset hair loss and those without hair loss (Matilainen 2001). In addition, early-onset androgenetic hair loss has been linked to an increased risk of metabolic syndrome in men (Banger 2015; Gopinath 2016), while female pattern hair loss has been associated with metabolic syndrome in women (Herskovitz 2013).
Prostate conditions. Research has not consistently found a connection between androgenetic alopecia and benign prostate enlargement, even though both are related to high levels of DHT (Arias-Santiago 2012; Dastgheib 2015; Qi 2014; Carson 2003). However, a review of studies concluded male pattern hair loss occurring at the crown of the head was associated with a 25% increase in prostate cancer risk (Amoretti 2013). Additional evidence found a 56% increase in prostate cancer deaths in men with any balding and an 83% increase in men with moderate balding, pointing to a relationship between male pattern hair loss and fatal prostate cancer (Zhou 2016).
Further evidence for this connection is found in research showing that use of finasteride, a 5-alpha reductase inhibitor that reduces serum DHT levels, is associated with reduced overall prostate cancer risk (Wilt 2008; Chau 2015); although it may be less effective at preventing high-grade than low-grade prostate cancers (Hoque 2015). Because some evidence suggests androgenetic alopecia may correlate with increased prostate cancer risk, men experiencing male pattern hair loss, especially those whose hair loss began at an early age, should monitor their prostate health and take steps to prevent prostate cancer. More information about keeping your prostate healthy is available in the Prostate Cancer Prevention protocol.
Causes and Risk Factors
Risk of hair loss increases with age and is higher in those with a family history of hair loss (Mayo Clinic 2015). While men have higher rates of androgenetic alopecia, women have a higher risk of telogen effluvium (Qi 2014).
Causes of Hair Loss
Causes of hair loss generally fall into five categories: hereditary, hormonal, medical, drug-related, and nutritional:
● Hereditary causes. Heredity is an important influence on age of onset, rate, and degree of hair loss (Mayo Clinic 2015).
● Hormonal causes. Hair loss is more common at times of hormonal changes such as during pregnancy, after childbirth, and with menopause.
Even the onset of puberty can mark the beginning of hair loss in some men (Mayo Clinic 2015). Other hormonal causes of hair loss include polycystic ovary syndrome (PCOS), hyperthyroidism and hypothyroidism (Mayo Clinic 2015; Goodman 2015; Levy 2013).
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Polycystic ovary syndrome. Polycystic ovary syndrome (PCOS), which affects about 5–10% of women, can lead to female pattern hair loss (Herskovitz 2013; Quinn 2014; Madnani 2013).
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Thyroid abnormalities. Both hyper- and hypothyroidism, as well as autoimmune thyroid disease with normal levels of thyroid hormone, are associated with alopecia areata (Lyakhovitsky 2015; Branisteanu 2014).
● Medical causes. Several medical conditions can cause hair loss:
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Some autoimmune diseases (Chen, Wang, Lin 2016)
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Tinea capitis, a fungal infection of the scalp (Ahanogbe 2015), psoriasis, seborrhea, and allergic contact dermatitis (Harrison 2009; Mubki 2014a)
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Trichotillomania (a psychological disorder characterized by hair pulling) (Ahanogbe 2015)
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Liver or kidney failure (Harrison 2009)
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Inflammatory bowel disease (Harrison 2009)
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Chronic infections such as HIV (Harrison 2009)
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Severe physical or emotional trauma (Harrison 2009; Ahanogbe 2015)
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Heavy metal poisoning (Harrison 2009)
● Drug causes.
Most drug-induced hair loss is reversible, and is generally due to telogen effluvium or anagen effluvium (Piraccini 2006; Tosti 2007). Many different medications have caused cases of hair loss, with only a few regularly causing this side effect. Cancer chemotherapy drugs, on the other hand, cause hair loss in most people who take them (Santos 2015; Llau 1995). Radiation therapy is another potential cause of hair loss in cancer patients (Qi 2014). General anesthesia during surgery has been associated with telogen effluvium (Desai 1984), although general stress associated with surgery may contribute as well. Some other drug categories that may cause hair loss include (Llau 1995; Mubki 2014a):
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Anticoagulants
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Beta-blockers
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Oral contraceptives
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Anti-thyroid medications
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Anti-seizure medications
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Retinoids o Amphetamines
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Mood stabilizers
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Antidepressants
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Antimicrobial and antiviral medications
● Nutritional causes. Severe protein and essential fatty acid deficiencies; overall malnutrition and crash diets; and iron, zinc, biotin, and vitamin D deficiencies can cause hair loss (Harrison 2009; Mubki 2014a). Other contributing factors. Unhealthy scalp and hair care practices can contribute to hair loss. The following practices may help prevent unnecessary hair damage and loss (Mayo Clinic 2015; AAD 2017):
● Avoid tight hairstyles that put pressure on the scalp, such as tight braids, buns, and ponytails.
● Avoid twisting, rubbing, and pulling on hair, and comb hair gently with a widetoothed comb.
● Avoid harsh hair treatments like hot rollers, curling irons, hot oil treatments, and permanents. (information source)
HR Growth Ingredients
Polygonium Multiflorum ext.
In recent years, people have begun to give further emphasis to the external beauty, espe- cially for their hair. Except drugs with proven effectiveness, complementary and alterna- tive treatment options that have not yet been clarified of their effectiveness and side effect profiles have been used for centuries. Many plants or their extracts are widely used to prevent hair loss and treat alopecia (e.g., androgenetic alopecia, alopecia areata, or trac- tion alopecia) worldwide, especially in Far Eastern countries. The mechanisms of action of these plants are still unknown. Although there are little randomized-controlled studies investigating the effectiveness in the treatment of hair loss, reported results have demon- strated that complementary and alternative medicine will become much more popular in the near future. The social and sexual communication roles of hair as well as its protective function have absolutely undeniable for both sexes for many years . Although the loss of hair is not a life-threatening condition, the loss of hair at an early age or sudden onset hair loss may cause serious psychological distress, thus it may directly affect the quality of life negatively. For this reason, patients with suffering from hair loss should be considered finically in order to distinguish ordinary hair shedding from pathologic hair loss. A loss of 100 or less hair fall- ing per day should not be considered as pathological hair loss. But in case of hair loss more than 100 per day, a pathological condition should be mentioned.
Hair loss is a common dermatological problem that has been estimated to affect between 0.2 and 2% of the world’s population. There are several factors leading to hair loss including major physicalemotional stress, chemotherapy, genetic predisposition, dihydrotestosterone (DHT), excessive sebum, cardiovascular diseases, smoking, and endogenous substances . The common hair diseases that dermatologists are often faced in daily practice are andro- genetic alopecia (AGA), alopecia areata (AA), telogen effluvium, anagen effluvium, and traumatic alopecia such as trichotillomania and traction alopecia]. AGA, known as male pattern hair loss in men and as female pattern hair loss in women, is the most common form of hair loss in adults. Approximately 60% of males between the ages 30 and 50 years and 17% of women under 50 years of age suffer from AGA . The role of DHT which is reduced from testosterone by enzyme 5α-reductase is clearly known in the mechanism of AGA . In early stage, the process begins with shortening of the anagen phase and continu- ous miniaturization of sensitive follicles . During this process, terminal hairs are replaced by vellus hairs which are shorter, finer and nonpigmented in the frontal and vertex regions of the scalp . Year after year, permanent baldness occurs at the site of miniaturized hair . AA is a common, chronic inflammatory disease that is characterized by non-scarring alopecic patches on the scalp. It affects approximately 2% of the United States (US) population . Although the mechanism of AA is exactly unknown, it is thought that a necessary secondary event or cofactor such as febrile illness, pregnancy, or a major life crisis in addition to genetic predisposition . Even though AA may regress spontaneously, the disease may remain stable or even may spread to the entire scalp (known as alopecia totalis) or body (known as alopecia universalis). Telogen effluvium is a disease that occurs as a result of passing of a portion of hair from anagen phase to telogen phase. It is characterized by diffuse hair shed- ding. While trichotillomania is an impulse control disorder, traction alopecia is association with patients’ hairstyle. These two diseases that occur after recurrent and chronic trauma are frequently seen in females than males. Both of them can result with permanent scarring. In recent years, complementary and alternative medicine (CAM) is becoming increasingly popular all over the world. In fact, CAM is still the only option to cure and treat some dis- eases in some regions of Africa, Asia, and South America.
Alternative medicine refers to the use of CAM in place of conventional medicine, while complementary medicine refers to the use of CAM along with conventional medicine . According to The National Center for Complementary and Alternative Medicine (NCCAM) in the United States, CAM is defined as ‘a group of diverse medical and healthcare system, practices, and products that are not pres- ently considered to be a part of conventional medicine’. In some countries like Korea, ori- ental medicine has been officially approved and has gained support from legal system using the licensing system . The number of visits to alternative care practitioners increased by about 1.5 times in 7 years (from 427 billion in 1990 to 629 billion in 1997) in the United States . The National Health Interview Survey estimated that in 2007 alone, 38% of adults in the United States used CAM Polygonum multiflorum (P. multiflorum, family Polygonaceae) is a very popular plant that has been widely used to treat various diseases in traditional Chinese medicine due to its dif- ferent pharmacological effects such as antiaging, immunomodulating, antihyperlipidemia, hepatoprotective, anticancer, and anti-inflammatory. Besides these pharmacological effects, some studies have been reported related to hair growth promotion activity and hair-blacking effect . An active component of P. multiflorum, known as 2,3,5,4ʹ-tetrahydroxystilbene- 2-O-β-d-glucoside (THSG), has melanogenesis-stimulating effect in melanocytes. A newcompound isolated from P. multiflorum, known as torachrysone-8-O-β-dglucoside, induces a strong increase in the proliferation of dermal papilla cells and significantly increases the hair- fiber length of rat vibrissa follicles . Li et al. investigated hair growth promotion activi- ties and their possible mechanism of P. multiflorum Radix (PMR) and P. multiflorum Radix Preparata (PMRP), both of them originated from P. multiflorum, in C57BL/6J mice. While hair covered skin ratio was higher in oral PMR groups than in PMRP groups, hair covered skin ratio was lower in topical PMR groups compared with topical PMRP groups. It was also dem- onstrated that the most possible cytokines regarding hair growth-promoting activity were fibroblast growth factor7 (FGF-7) and Shh . Another animal study suggested that anagen phase was induced in resting hair follicles through upregulating Shh and β-catenin expres- sion after topical application of P. multiflorum (information source)
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Alopecia Areata Treatment
For many people with alopecia areata, the condition is primarily a cosmetic concern (Messenger 2021). However, hair is an important aspect of a self-image and hair loss can be deeply emotionally and psychologically distressing for some people with alopecia areata (Messenger 2021; NAAF 2022a). Thus, psychosocial support is a central component of management. There is no curative treatment for alopecia areata, and evidence for the effectiveness of existing treatments is limited (Messenger 2021). However, a promising step forward occurred in June 2022 when the FDA approved the first systemic treatment for alopecia areata—the Janus kinase (JAK) inhibitor baricitinib (Olumiant).
In AA, inflammation causes a large proportion of hair follicles to shift from the anagen phase to the telogen phase. In the acute stages of AA, most hair follicles are still in the anagen phase. If one were to perform a scalp biopsy at this stage, the histologic examination would reveal an excessive amount of lymphocytes in and around the hair follicle. While the normal ratio of anagen to telogen hairs in the scalp is usually 80:20, patients with AA exhibit a 60:40 or even 50:50 anagen to telogen ratio, and in some cases the number of telogen hairs might dominate.
In AA, inflammation causes a large proportion of hair follicles to shift from the anagen phase to the telogen phase. In the acute stages of AA, most hair follicles are still in the anagen phase. If one were to perform a scalp biopsy at this stage, the histologic examination would reveal an excessive amount of lymphocytes in and around the hair follicle. While the normal ratio of anagen to telogen hairs in the scalp is usually 80:20, patients with AA exhibit a 60:40 or even 50:50 anagen to telogen ratio, and in some cases the number of telogen hairs might dominate.
Several types of Chinese herbal remedies are available that can help treat this condition. One substantial advantage Chinese medicine has over Western conventional treatments is that the former addresses the root cause of the problem while the latter only masks the symptoms. Chinese medicine helps bring back balance in the body, causing the symptoms to dissipate eventually and curing the condition. In alopecia areata, Chinese medicine believes that there are two patterns responsible for the symptomatic loss of hair. One pattern is a deficiency of Kidney and Liver Yin. This means that there is a deficiency in the energy that normally nourishes the hair follicles. Hair starts to grow back when herbs that nourish the Yin of Kidney and Liver are used. The other pattern is the accumulation of Toxic Heat in the body, which means that there is inflammation in the body caused by its exposure to toxins or pollution, excess acidity stemming from a poor diet, or infection.
Most Alopecia areata sufferers usually have both or infection. Most Alopecia areata sufferers usually have both conditions.
An herb known as He Shou Wu, Fo-ti , or polygonum the main ingredient in HR-GROWTH capsules,can help people with alopecia areata. In China, polygonum has been a traditional treatment for premature hair loss and graying hair. This herb can serve as a tonic for both the brain and the body, and can boost the quality of hair growth on the scalp. To attain its full benefits, use polygonum for three to six months. It is also used as a longevity tonic by the Chinese. (information source)
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MSM, VITAMIN E, VITAMIN B1, B2, B5 and B6, ZINC PICOLINATE
Their function in the formulation is as trace elements.
What are trace elements in nutrition?
Nutritionally essential trace elements are required parts of an individual’s nutrition. These elements contribute to vitalbodily functions, including metabolic function, tissue repair, growth, and development. Because the human body cannot naturally synthesize these elements, it is essential that people consume them through their diet or by using supplements. Trace elements refer to any chemical element that is present in the body in very small amounts. Trace elements can be classified as nutritionally essential, probably essential, or potentially toxic. The nutritionally essential elements are required for proper physiological and metabolic functions. At least 21 trace elements have been described in the human body and each one has different functions. Deficiencies or excess of any of the trace elements can cause various clinical manifestations and affect one’s growth and development.
(information source)
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Equisetum Arvensis
The botanical name for horsetail is Equisetum arvense. It contains high amounts of silica, which is a compound that strengthens hair and nails. In fact, horsetail is one of the plants that contain the highest amount of silica. The plant grows naturally in the Middle East, Europe, and Asia. Generally, horsetail has leaves that are arranged in sheaths and hollow stems. How does it benefit hair? Horsetail extract is known to improve the circulation of your blood, which in turn leads to healthy hair follicles. It has antioxidant properties that also work as a detox for your hair and body. When your scalp gets enough blood, it increases its ability to produce more hair. The silica in horsetail has been shown to encourage hair growth and hair thickness. Using this extract also impacts your collagen production in a positive way that will improve your hair health and overall look. (information source)
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Stinging nettle
There aren’t a lot of quality studies on stinging nettle, or Urtica dioica, for hair growth, but one study showed that taking this herbal extract increased dermal papilla cell growth. These cells are part of the hair follicle and regulate hair growth. Another study showed that stinging nettle is rich in a plant chemical called beta-sitosterol, which raises growth factors that stimulate hair growth. (information source)
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American Ginseng
Ginseng is an ancient herbal remedy that was recorded in The Herbal Classic of the Divine Plowman, the oldest comprehensive Materia Medica, which was scripted approximately 2000 years ago.
Ginseng biochemical effects on hair growth promotion:
The major bioactive constituents of ginseng are ginsenosides and there has been evidences suggesting that promote hair growth by enhancing proliferation of dermal papilla and preventing hair loss via modulation of various cell-signaling pathways [9, 16, 17].
Ginseng in Hair Growth and Viability:
The role of 5α-reductase enzyme in the hair-loss process has been well- documented [18], affects androgen metabolism, and it is the pathway how drugs approved are used nowadays.
Novel therapeutics ways for the management of hair loss and alopecia improving hair-follicle proliferation and reducing hair-loss need new targets (Figure 2). These targets include, matrix metalloproteinases (MMPs), extracellular signal-regulated protein kinase (ERK), and Janus-activated kinase (JAK), the activation of the pro- liferation by WNT/Dickkopf homolog 1 (DKK1), sonic hedgehog (Shh), vascular endothelial growth factor (VEGF), apoptosis inhibition by transforming growth factor-beta (TGF-β).
Ginseng on androgen alopecia:
The exposure to androgens is the major triggers for hair loss is which in most cases is genetically predetermined in androgenic alopecia patients [9, 31, 32].
The androgen that mainly plays a role in altering hair cycling is 5α-dihydrotestosterone (DHT), which is a metabolite of testosterone. The conver- sion of testosterone to DHT is mediated by the 5αreductase (5αR) enzyme in each follicle [33, 34] (Figure 2). Treatment with 5α-reductase inhibitors, e.g., finasteride, prevents the development of alopecia and increases scalp-hair growth [9]. Topical application of ginseng extract or ginsenosides was reported to enhance hair growth. Rhizomes of P. ginseng (red ginseng) containing a considerable amount of ginsenoside Ro, Ro is the predominant ginsenoside in the rhizome showed greater dose-dependent inhibitory effects against testosterone 5α-reductase (5αR) [35]. Ginsenoside Rg3 (a unique ginsenoside in red ginseng) and Rd. also exhibited similar inhibitory effects against 5αR [36]. Another variety of ginseng, the Parribacus japonicas rhizome extract that contains a larger quantity of ginsenoside Ro also inhibited 5αR enzyme activity. Topical administration of red-ginseng rhizome extracts and ginsenoside Ro onto shaved skin of C57BL/6 mice abrogated testosterone-mediated suppression of hair regrowth [36]. Major components of hair regenerative capacity such as linoleic acid (LA) and β-sitosterol (SITOS) were significantly restored with Red Ginseng Oil (RGO) after testosterone (TES)-induced delay of anagen entry in C57BL/6 mice, also RGO and its major components reduced the protein level of TGF-β and enhanced the expres- sion of anti-apoptotic protein Bcl-2, suggesting that RGO is a potent novel thera- peutic natural product for treatment of androgenic alopecia [37]. Red Ginseng Extract (RGE) and ginsenosides protect hair matrix keratinocyte proliferation against dihydrotestosterone (DHT)- induced suppression and affects the expression of androgen receptor. Moreover, RGE, ginsenoside-Rb1, and ginsenoside-Rg3 at lower levels that have been shown to inhibit 5a-reductase [35] inhibit the DHT-induced suppression of hair matrix keratinocyte proliferation and the DHTinduced upregulation of the mRNA expression of androgen receptor in hDPCs [16].DHT is the product of testosterone and does not require the activity of 5a-reductase to affect hair follicles, and the inhibitory effect of DHT on hair growth is mediated by the androgen rece tor in DPCs [38] These results suggest that red ginseng may promote hair growth in humans through the regulation of androgen receptor signaling. (information source)