Chole-Treat
A natural supplement designated to cholesterol levels
Chronic exposure to a high-fat diet can lead to an accumulation of cholesterol in the blood. An elevated plasma total cholesterol (TC) level is a recognized risk factor for coronary heart disease, atherosclerosis, and strokes.
Successful management of cholesterol metabolism disorders can effectively prevent these diseases.
There is growing evidence that gut microbiota dysbiosis strongly influences the development of cholesterol metabolism.
Statins are currently the most effective cholesterol-lowering drugs. However, their long-term use can have side effects such as hepatotoxicity and muscle toxicity.
Therefore, there is a need to develop nutritional interventions with no side effects.
Each package contains: 120 caps
Recommended use: 2 caps twice a day
Chole-Treat Benefits
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beneficial effects on cardiovascular disease risks
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aid in decreasing cholesterol levels and to improve overall heart health and function
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significantly reducing total cholesterol and LDL-cholesterol concentrations and may be useful as a treatment for high blood pressure.
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possesses antidiabetic activity and have significant effect on cholesterol and triglyceride level.
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anti-inflammatory, antitumor and anti-obesity activities
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can inhibit hepatic HMG-CoA reductase and promote the excretion of acidic sterol
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increase HDL
Description
As we know, coronary artery disease (CAD) is one of the most important causes of deaths all over the world.
Epidemiological reports have demonstrated that the high risk of CAD is associated with dyslipidemia, especially the high level of low density lipoprotein-cholesterol (LDL-C). One of the considerable first line for treating dyslipidemia is dietary regulations and recommendations;
however, using these methods, only a modest amelioration can be achieved. (information source)
Early studies by Anitschkow demonstrated that cholesterol administration results in symptoms of atherosclerosis, contributing to the lipid hypothesis, formulated by Duff and McMillan, which proposed an association between cholesterol and cardiovascular diseases (CVD).
CVD are the leading cause of global mortality and morbidity and kill an estimated 16.7 million people worldwide. Coronary artery disease (CAD), the most common CVD, is the leading cause of death and accounts for 7.25 million deaths globally. The first line of treatment for CAD, dietary and lifestyle interventions, has proven inadequate. (information source)
(information source)
Hyperlipidemia is defined as increase in lipid content in blood and lipid associated disorders which are based not only on total serum cholesterol, but also on the distribution amongst different lipoproteins. The low-density lipoproteins (LDL) are the major carriers of cholesterol towards the tissues having atherogenic potential, whereas high density lipoproteins (HDL) carry cholesterol from peripheral tissues to the liver, protecting system from many cardiac problems
and obesity. Thus, hyperlipidemia is characterized by elevated levels of LDL and decreased level of HDL in the blood. Hyperlipidemia is the primary risk factor of coronary heart disease and atherosclerotic heart disease. There are wide range of antihyperlipidemic drugs available in the market, but most of them have side-effects. Herbal medicines are being accepted and used increasingly by general population both in eastern and western countries because of their ethnic acceptability and compatibility, having less side-effects. (information source)
Chole-Treat Ingredients
Black walnut hull
Black walnut is rich in phenolics and contains higher levels of phytosterols, unsaturated fatty acids and tocopherols than many other commonly consumed nuts. Dietary intervention of these constituents has been associated with a great number of disease-preventive properties.
Black walnut has a potential to inhibit the release of proinflammatory mediators in vitro. Similarities in contents of unsaturated fatty acids and tocopherols between black walnut and English walnut suggest that black walnut consumption may produce beneficial effects on cardiovascular disease risks. In addition, the high level of γ-tocopherol in black walnut could make the nut a cancerpreventive option. (information source)
The nuts of the black walnut are believed to aid in decreasing cholesterol levels and to improve overall heart health and function. Few studies have shown that black walnut significantly reduced total cholesterol and LDL-cholesterol concentrations and may be useful as a treatment for high blood pressure. (information source)
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Swertia Chirata extract (Gentianaceae)
Swertia chirata is generally consumed by the older people and/or people with type 2 diabetes mellitus as it is useful for lowering the blood glucose level. Ethanolic extract possesses antidiabetic activity and have significant effect on cholesterol and triglyceride level. The Gentianaceae is one of the larger and most important families having a large number of genera and species in the flora of world. The genus Swertia has been well-known for its botanical diversity and pharmaceutical uses in traditional and folk medicine which is a very important part of indigenous cultures worldwide.
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Artemisia Judaica extract
Artemisia annua is described to have anti-hyperlipidemic, antiplasmodial, anti-convulsant, antiinflammatory, anti-microbial, anticholesterolemic and antiviral properties.
Artemisia annua would also have important pharmacological activities such as anti-inflammatory, antitumor and anti-obesity activities that contribute to the therapeutic effects of the plant.
Artemisia annua has also an interesting nutritional profile with the presence of amino acids, vitamins and minerals and essential elements for health. Since its discovery, Artemisia annua has been the subject of extensive research on its chemical composition. More than 600 secondary metabolites have been identified throughout the plant, including several sesquiterpenoids, triterpenoids, monoterpenoids, steroids, flavonoids, coumarins, alkaloids and benzenoids.
Thanks to this richness, Artemisia annua has a large number of other biological properties such as hepatoprotective, antifungal, antitumor, antioxidant, anti-inflammatory and anti-asthmatic activities. (information source)
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Lactobacillus Reuteri
Probiotics are defined by the World Health Organization as live microorganisms that provide health benefits to the host when given in sufficient amounts and are presently being evaluated for their efficacy in lowering TC and low-density lipoprotein cholesterol (LDL-C) levels in humans. Some probiotics, mainly Lactobacillus and Bifidobacterium, have potential cholesterol-lowering benefits in the gastrointestinal tracts of mammals. (information source)
There has been increasing interest in probiotics, “microorganisms which when administered in adequate amounts confer a health benefit on the host,” research for the development of biotherapeutics. In recent years, attention has been given to the ability of probiotic cells to reduce lipids and cholesterol levels, with several proposed mechanisms of action. One mechanism, bile salt hydrolase activity, is described in a recent review. In addition, bacteria have been reported to assimilate cholesterol, thereby lowering luminal cholesterol levels available for absorption. Moreover, Lactobacillus bacteria can produce ferulic acid (FA), which can inhibit hepatic HMG-CoA reductase and promote the excretion of acidic sterol. With the demonstrated cholesterol-lowering properties of probiotic bacteria, further research is required to investigate the mechanism(s) by which the bacteria decrease cholesterol levels and to select bacteria capable of exerting cholesterol-lowering effects. (information source)
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Mukul Myrh extract
Guggul, also known as guggulu and guggulipid, is a substance secreted by the mukul myrrh tree (Commiphora mukul) after it has been injured. It has been used in Indian Ayurvedic medicine for centuries to treat obesity, osteoarthritis, and some skin conditions. Research has suggested that guggul also may lower total cholesterol levels, especially triglycerides, and LDLcholesterol. (https://www.verywellhealth.com/can-guggul-lower-cholesterol-698010)
Guggul, an oleo gum-resin, is plant exudates of Commiphora wightii (Arnott.) Bhand.
Commiphora mukul Engl., belonging to family Burseraceae (Genus: Commiphora) and has been in use medicinally since Vedic period for treatment of a number of diseases such as atherosclerosis, hypercholesterolemia, rheumatism, obesity, respiratory diseases, liver disorders, digestive problems, menstrual irregularities. Guggul of Commiphora mukul/Commiphora wightii possess lipid lowering effect. In various experimental and human studies, Commiphora mukul has shown to decrease atherosclerosis, lower serum cholesterol and triglycerides (TGs), and also increase HDL and cholesterol (information source)