ADHDone
A herbal formula on a natural basis designed to help in cases of hyperactivity, attention and concentration.
What is ADHD?
ADHD is classified as a mental disorder in which children (and some adults) demonstrate persistent lack of attention to tasks (attention deficit) and/or an inability to control impulses and an increase in physical activity (hyperactivity) that is not typical for people at a similar stage of development.
Each package contains: 30 sachets.
Recommended use: Pour a bag into half a glass of water and drink on an empty stomach once a day.
ADHDone Benefits
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Favorable tolerability.
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No effect on appetite, mood.
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No cardiovascular effect.
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No potential for abuse or addiction seen.
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Fixed dose (no need for dose titration).
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ADHDONE is a GABA modulator, and it reduces Akt and ERK hyperactivation.
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ADHDONE is a 5-HT2B receptor antagonist.
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Most ADHD medications (stimulants and Strattera) work by increasing monoamines (dopamine, norepinephrine, serotonin) in the brain.
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ADHDONE shows no effect on dopamine, norepinephrine, or serotonin levels in vivo.
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ADHDONE shows no binding to dopamine, norepinephrine, or serotonin transporters in vitro.
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ADHDONE binds the GABA transporter.
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ADHDONE displays a dose-dependent, reversible enhancement of GABAergic inhibitory transmission via presynaptic mechanisms in a type of neurons called striatal medium spiny neurons.
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ADHDONE does not work via the metabotropic glutamate receptor (mGluR).
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Statics show that methylphenidate use increased 2.5fold from 2006 to 2016 (7.9 to 20.0 tons). Methylphenidate use, at 16.5 tons in 2006, peaked in 2012 (19.4 tons) and subsequently showed a modest decline (18.6 tons in 2016).
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Efficacy of more than 80%
Description
What is ADHD?
ADHD is classified as a mental disorder in which children (and some adults) demonstrate persistent lack of attention to tasks (attention deficit) and/or an inability to control impulses and an increase in physical activity (hyperactivity) that is not typical for people at a similar stage of development.
Children with ADHD have changes in brain function that may arise from abnormalities in cell membranes, blood flow, and levels of signaling chemicals (neurotransmitters) such as dopamine and norepinephrine. Stimulant drugs such as Ritalin® promote the release of such chemicals in brain tissue. Limited effectiveness, safety problems, and high costs of many psychotropic medications have resulted in an urgent mandate for safer, more effective and more affordable treatments of mental illnesses. After decades of research and billions of dollars of industry funding, the evidence supporting widely used pharmacologic treatments of major depressive disorder, bipolar disorder, schizophrenia, and other psychiatric disorders is not compelling. These issues have led increasing numbers of individuals with mental health problems to seek treatment from complementary and alternative medical (CAM) practitioners, including Chinese medical practitioners, naturopathic doctors, herbalists, chiropractors, homeopathic physicians and others.
ADHDone Ingredients
Vitamin B6 (pyridoxine)
If a child has a known deficiency of B vitamins, supplementation may be helpful. Vitamin B6 (pyridoxine) is essential in the manufacture of many neurotransmitters that are important for healthy brain function, with potential applications for fighting ADHD. One study found that vitamin B6 supplements were as effective as Ritalin® in decreasing hyperactivity, and that the vitamin's effects persisted even after supplementation was stopped. (According to inner research of Homeotreat).
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Dry saffron extract
The bioactive constituents of saffron increases reuptake inhibition of dopamine and norepinephrine and functions as both N-methyl D-aspartic acid (NMDA) receptor antagonists and GABA-a agonists. Both mechanisms are believed to mediate beneficial effects on symptoms of inattention. (According to inner research of Homeotreat).
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Dry American ginseng extract
Ginseng’s therapeutic effects are most widely investigated in respect to the central nervous system (CNS) diseases. These include Alzheimer, Parkinson’s, cerebral ischemia, depression, and many others neurological disorders including neurodevelopmental disorders. Ginseng exerts its effect also on diverse array of target pathways or molecules. These range, for example, from neuroprotection to the regulation of synaptic plasticity and from regulation of neuroinflammatory processes to the regulation of neurotransmitter release, too many to mention. In general, ginseng and even a single compound of ginsenoside produce its effects on multiple sites of action, contributing to ADHDONE’s multi-target formulation. (information source)
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L-glutamine amino acid
Glutamine is an amino acid (a building block for proteins), found naturally in the body Glutamine is also used for attention deficit-hyperactivity disorder (ADHD). (information source)
There is increasing evidence that abnormalities in glutamate signaling may contribute to the pathophysiology of attention-deficit hyperactivity disorder (ADHD). Impaired glutamate signaling is another possible underlying abnormalities in (some cases of) ADHD, and an emerging treatment target.10 Glutamate is an amino acid involved in excitatory neurotransmission.11 Further, glutamate and dopamine interact, with glutamate modulating dopamine release in corticostriatal pathways and vice versa. (information source)
Most beliefs on glutamine stem not from studies that glutamine itself works, but from the results of GABA on anxiety. GABA is a neurotransmitter formed from glutamine that is known to have anxiety reducing benefits. GABA itself is affected by several anxiety drugs in order to produce these anxiolytic effects. (information source)
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Vitamin B3 (Nicotinic acid)
Vitamin B complex plays an important role in the functioning of the methylation cycle involved in monoamine oxidase production, the synthesis of DNA, RNA, protein and phospholipids, and in cell repair. The methylation cycle ensures proper immune function and inflammatory balance, maintains DNA, provides energy, and balances mood behaviors. Lowered methylation function is associated with a range of chronic conditions, including numerous neurological conditions, such as autism, schizophrenia, Alzheimer’s disease, psychiatric disorders, mood behaviors and depression. (information source)
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ADHDONE Proposed Mechanism of Action:
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ADHDONE is a monoamine-independent GABA transmission modulator.
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ADHDONE is a 5-HT2B receptor antagonist.
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ADHDONE binds the GABA transporter.
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ADHDONE displays a dose-dependent, reversible enhancement of GABAergic inhibitory transmission via presynaptic mechanisms in a type of neurons called striatal medium spiny neurons.
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ADHDONE does not work via the metabotropic glutamate receptor.